Are you up to date on your maintenance? If so, check all your fluids. If concerned, take it to a trusted mechanic for a pre-vacation check-up. But check your maintenance records first. Then check your auto insurance to see if you have road service coverage and how it works (or look for your AAA card and make sure you know where it is). If you don't have road service, look up the instructions in your owner's manual for the jack location & use & check the air pressure in your spare when you check the rest of your tires (before you leave!).
Good luck and have a safe vacation!