Quality, in vehicular terms, is actually more subjective than you may think. Of course, the factors themselves are mostly objective, however when one hops into a car, they judge often by the impression they get from the car's "feel."
For me, what gives me a good quality "feel" is:
1. Material
2. Stability
3. Reliability
4. Comfort
5. Design
Japanese and German brands usually, but not always have good quality. Some say domestic brands have improving quality, but this is only parially true. More than being foreign or domestic, however, is the brand itself, or even vehicle. For example, a Honda has much better build quality than a Mitsubishi, but they both are from Japan. A Malibu is so much more refined than an Aveo, you'd think they were by entirely different companies (oh, that's right... the Aveo is a Korean Daewoo...).
Currently, as for a "mainstream" automaker, the answer to the best quality would probably be Honda. Volkswagens aren't quite as "mainstream," but they do have great refinement. However, Volkswagens have awful reliability, and to buy one would be... well... "suicidal" in car terms.
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